说明书 
ERCC2（p.N238S）点突变5637细胞基于新开发的Bingo™平台，该平台采用优化升级版的Prime Editing (PE)基因点突变系统——目前最高效、最安全的技术。该平台可以实现精准、高效的基因点突变，从而获得高活性和稳定的细胞系。艾迪基因拥有大量的PE点突变细胞库存，能够高效、及时地提供高质量的产品。
| 货号 | EDC03194 |
|---|---|
| 产品名称 | ERCC2（p.N238S）点突变5637细胞 |
| 物种 | 人 |
| 细胞 | 5637 |
| Cellosaurus ID | CVCL_0126 |
| 突变位点 | p.N238S |
| 基因 | ERCC2 |
| 基因ID | |
| 摘要 |
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
|
| 癌症类型 | Bladder Carcinoma |
| 传代比率 | 1:4 |
| 完全培养基 | 1640+10%FBS |
| 冻存培养基 | 92% 完全培养基+8% DMSO |
* 仅供科研使用，不适用于人体或动物，包括临床、治疗或诊断用途。
| Loci | 送检细胞STR信息 送检细胞名: 5637 | 细胞库细胞STR信息 细胞库细胞名: 5637 | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| Amelogenin | X | X | Y | |
| CSF1PO | 11 | 11 | ||
| D2S1338 | 25 | 25 | ||
| D3S1358 | 15 | 17 | 15 | 17 |
| D5S818 | 11 | 12 | 11 | 12 |
| D7S820 | 10 | 11 | 10 | 11 |
| D8S1179 | 10 | 16 | 10 | 16 |
| D13S317 | 11 | 11 | ||
| D16S539 | 9 | 9 | ||
| D18S51 | 16 | 18 | 16 | 18 |
| D19S433 | 13 | 15 | 13 | 15 |
| D21S11 | 36 | 36 | ||
| FGA | 22 | 22 | ||
| Penta D | 11 | 11 | ||
| Penta E | 10 | 12 | 10 | 12 |
| TH01 | 7 | 9 | 7 | 9 |
| TPOX | 8 | 8 | 9 | |
| vWA | 18 | 18 | ||
| D6S1043 | 16 | 20 | 16 | 20 |
| D12S391 | 20 | 20 | ||
| D2S441 | 14 | |||
* 该细胞系与收录于ATCC, DSMZ, JCRB 和 RIKEN数据库的细胞系STR数据匹配。
结论：该细胞 STR 鉴定正确。
结论：该细胞 STR 鉴定正确。
* 研究用途免责声明：本内容基于公开的研究数据、生物信息学资源及计算分析生成，仅供研究参考。
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