JAK1（p.R659=）点突变HAP1细胞
货号:
EDC03512
物种:
人
细胞名称:
HAP1
基因名称:
JAK1
基因ID:
3716
JAK1（p.R659=）点突变HAP1细胞基于新开发的Bingo™平台，该平台采用优化升级版的Prime Editing (PE)基因点突变系统——目前最高效、最安全的技术。该平台可以实现精准、高效的基因点突变，从而获得高活性和稳定的细胞系。艾迪基因拥有大量的PE点突变细胞库存，能够高效、及时地提供高质量的产品。
| 货号 | EDC03512 |
|---|---|
| 产品名称 | JAK1（p.R659=）点突变HAP1细胞 |
| 物种 | 人 |
| 细胞 | HAP1 |
| 突变位点 | p.R659= |
| 细胞别名 | HAP-1 |
| 基因 | JAK1 |
| 基因ID | |
| 摘要 |
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020]
|
| 细胞形态 | 贴壁生长 |
| 传代比率 | 1:8~1:10 |
| 完全培养基 | IMDM+10%FBS |
| 冻存培养基 | 90%FBS+10%DMSO |
* 仅供科研使用，不适用于人体或动物，包括临床、治疗或诊断用途。
* 研究用途免责声明：本内容基于公开的研究数据、生物信息学资源及计算分析生成，仅供研究参考。
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